Immunohistochemical and histological evaluations of cyclophosphamide-induced acute cardiotoxicity in wistar rats: The role of turmeric extract (curcuma)
RatChemical/toxinWistarmalen = 35 Wistar rats in 7 groups of 5 (N=5 per group)Oral100 mg/kg or 200 mg/kg turmeric ethanol extractPretreatment for 72 hours before cyclophosphamide administration (groups D and…
Model: Acute cardiotoxicity induced by cyclophosphamide 100 mg/kg intraperitoneally for 10 days, acting through its toxic metabolite acrolein, assessed in the left ventricular myocardium
Cyclophosphamide alone significantly lowered body weight change, creatine kinase-MB and lactate dehydrogenase and produced morphological alterations in left ventricular myocardium on histology and immunohistochemistry. Turmeric ethanol extract, given either as 72 hour pretreatment or concomitantly…
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