Design, Implementation, and in Vivo Validation of a Novel Proton FLASH Radiation Therapy System
Model: Radiation-induced intestinal injury from whole abdominal or focal intestinal proton irradiation, assessed as acute crypt cell loss at 3.5 days and intestinal fibrosis at 8 weeks; some mice also carried subcutaneous flank tumours from MH641905 cells derived from the KPC autochthonous pancreatic cancer model (5 x 10 to the power of a stated number of cells, exact count not rendered in the retrieved text)
After 15 Gy whole abdominal irradiation, FLASH proton radiotherapy preserved significantly more proliferating EdU-positive cells per crypt and a significantly higher percentage of regenerated crypts than standard dose rate proton radiotherapy, although both remained below non-irradiated tissue. Aft…
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