Intravenous Immunomodulatory Nanoparticle Treatment for Traumatic Brain Injury
Model: Two experimental traumatic brain injury models: controlled cortical impact (3 mm craniotomy, 2 mm impactor tip, 2 mm cortical deformation at 3.00 m/s with 30 second dwell, targeting visual or sensorimotor cortex) and moderate weight-drop closed head injury (240 g weight dropped 1.4 m onto the anaesthetised mouse resting on prescored foil)
In controlled cortical impact, nanoparticle treatment cut total cells in the lesion area by 44.0%, infiltrating macrophages/monocytes by 84.5%, overall myeloid cells by 65.8% and Ly6C inflammatory monocytes by 72.4% at 72 hours, and reduced lesion volume by 44.7% at 10 weeks with a less intense per…
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