Carbon Monoxide Rescues the Developmental Lethality of Experimental Rat Models of Rhabdomyolysis-Induced Acute Kidney Injury
RatCrushLimb / muscle crushSprague-Dawley
Model: Rat models of acute kidney injury induced by traumatic and non-traumatic rhabdomyolysis, comprising crush syndrome, rhabdomyolysis combined with massive haemorrhagic shock, and glycerol-induced rhabdomyolysis
A single CO-RBC treatment suppressed the pathogenesis of acute kidney injury and improved mortality in crush syndrome and in rhabdomyolysis with massive haemorrhagic shock model rats, and likewise reduced acute kidney injury and mortality in glycerol-induced rhabdomyolysis rats, with renoprotection…
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