Effects of Receptor for Advanced Glycation End-Products (RAGE) Signaling on Intestinal Ischemic Damage in Mice.
MouseIschaemia-reperfusionIntestinal / mesentericC57BL/6Intraperitoneal
Model: Irreversible transmural intestinal necrosis induced by clipping the cranial mesenteric artery and peripheral blood vessels
RAGE ligands S100A8/A9 and S100beta were markedly elevated during intestinal ischaemic necrosis and impeded epithelial regeneration in vitro, supporting RAGE as a therapeutic target, while the in vivo effect of the inhibitors is not quantified in the abstract.
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