Effects of a potassium channel opener on brain injury and neurologic outcomes in an animal model of neonatal hypoxic-ischemic injury.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyMalen = n = 12 vehicle-treated hypoxia-ischaemia rats used for corr…Intraperitoneal25 mg/kg per dose (12 mg flupirtine maleate in 1 ml DMSO, f…First dose 5 minutes after return to room air at the end of the 2 h hypoxia, th…
Model: Rice-Vannucci neonatal hypoxia-ischaemia: double ligation of the right common carotid artery under isoflurane, 2 h recovery with the dam, then 2 h hypoxia at 8 to 8.3 percent oxygen, 36.5 degrees C, 60 to 70 percent humidity
Flupirtine reduced acute hippocampal tissue loss (28.71 versus 60.66 percent, P = 0.007) and cortical tissue loss (14.4 versus 27.54 percent, P = 0.037) and partially reversed spatial learning deficits and contralateral hippocampal volume loss, but did not improve motor grip strength or chronic ips…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.