Selective Modulation of A1 Astrocytes by Drug-Loaded Nano-Structured Gel in Spinal Cord Injury
MouseSpinal cord injuryUnspecifiedC57BL/6Acute administration after spinal cord injury
Model: Mouse spinal cord injury model (specific injury method and severity not stated in the abstract), complemented by in vitro work on activated mouse and human astrocytes and motor neurons
Nanogel-delivered rolipram was selectively internalised by activated astrocytes, limited the inflammatory response of A1 astrocytes by reducing iNOS and Lcn2, and reversed astrocyte-mediated toxicity towards motor neurons, showing an advantage over conventional administration. In the mouse spinal c…
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