Creating a Favorable Microenvironment for Fat Grafting in a Novel Model of Radiation-Induced Mammary Fat Pad Fibrosis.
RatRadiationn = 10 irradiated and 10 non-irradiated mammary fat padsIntramammary injection
Model: Rat mammary fat pad irradiated with a single dose of 26 Gy to induce radiation-induced fibrosis of breast tissue
Peptide treatment reduced radiation-induced fibrosis, increasing the collagen 3 to 1 ratio and lowering expression of the collagen-1 crosslinking enzymes lysyl oxidase and transglutaminase 2 as well as transforming growth factor beta 1 protein, while increasing the antifibrotic adipokine adiponecti…
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