Acute upregulation of bone morphogenetic protein-4 regulates endogenous cell response and promotes cell death in spinal cord injury.
RatSpinal cord injuryContusionSprague-DawleyFemaleAdministered during the acute phase after spinal cord injury
Model: Preclinical rat model of compressive and contusive traumatic spinal cord injury, with parallel in vitro work on neural precursor cells, oligodendrocyte precursor cells, neurons and astrocytes
Active BMP4 was robustly and transiently upregulated after injury. Acute blockade of BMPs with noggin or LDN193189 promoted oligodendrogenesis, oligodendrocyte preservation and remyelination, and markedly attenuated caspase-3 activation and lipid peroxidation. BMP4 directly induced caspase-3 mediat…
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