Enhancement of cellular activity in hyperglycemic mice dermal wounds dressed with chitosan-alginate membranes.
MouseWoundC57BL/6JMalen = 5 animals per group for the reported analysesTopical, applied directly onto the dorsal excision siteOne circular membrane 6 mm in diameter per lesion, pre-mois…Applied immediately after wounding, on the same day diabetes was confirmed
Model: Two 6.0 mm full-epidermis-removal punch excision wounds on the dorsum of streptozotocin-induced hyperglycaemic mice (streptozotocin 60 mg/kg per day intraperitoneally for 5 days; blood glucose above 250 mg/dL)
Membrane-treated wounds were smaller on day 6, showed complete reepithelialisation and more organised collagen by day 10, had fewer leukocytes, vessels and fibroblasts on days 5 and 10, and showed an early rise in IL-1 alpha, IL-1 beta, G-CSF and TNF-alpha followed by falls in G-CSF, TNF-alpha and…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.