Inhibiting store-operated calcium entry attenuates white matter secondary degeneration following SCI.
MouseSpinal cord injuryComplete transectionCNPase:Thy1 double transgenic and Advillin-Cre:Ai9 mice (C57BL/6 background per MeSH)male and female (per MeSH indexing)n = Ex vivo: 5 treated and 8 controls. In vivo: 5 mice per grou…1 hour after injury (delayed treatment)
Model: Laser-induced focal transection of mid-cervical dorsal column axons in ex vivo spinal cord preparations, plus mild 30 kdyn contusion in vivo
Delayed YM-58483 reduced intra-axonal calcium accumulation and axonal dieback, limited secondary axonal damage and improved oligodendrocyte and axonal survival relative to controls.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.