PRECLINICAL PUBLICATION · 2019

A self-assembling peptide hydrogel-based drug co-delivery platform to improve tissue repair after ischemia-reperfusion injury.

Mouse / Ischaemia-reperfusion

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

TNF-alpha neutralising antibody plus hepatocyte growth factor co-delivered in a self-assembling peptide (KLD2R)/heparin hydrogel

PMID 31843715 ↗2019Reported benefit

A self-assembling peptide hydrogel-based drug co-delivery platform to improve tissue repair after ischemia-reperfusion injury.

MouseIschaemia-reperfusionRenalC57BL/6 (per MeSH)male (per MeSH)Injection of the hydrogel (single injection)

Model: Renal ischaemia-reperfusion injury in mice

Hydrogel co-delivery of anti-TNF-alpha and HGF lowered serum creatinine, blood urea nitrogen, tubular apoptosis and inflammation and reduced later fibrosis compared with free drug or hydrogel alone.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.