B-RAF Inhibitor Dabrafenib Attenuates RIPK3-Mediated Necroptosis and Promotes Functional Recovery after Spinal Cord Injury.
MouseSpinal cord injuryContusionC57BL/6Jfemalen = 12 per group in the locomotor cohort; other per-group n not…Oral gavage100 mg/kg in 200 microlitres of 0.5 per cent hydroxypropyl…4, 24 and 48 hours after injury
Model: Thoracic (T10) contusion spinal cord injury using a modified MASCIS impactor, 10 g rod with 1.5 mm tip dropped from 3 mm
Acute oral dabrafenib reduced RIPK3 and phospho-MLKL expression and necrotic cell numbers, preserved white matter, neurons and axons, shortened motor evoked potential latency and improved locomotor and sensory recovery versus vehicle.
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