The Construction of a Radiation-Induced Brain Injury Model and Preliminary Study on the Effect of Human Recombinant Endostatin in Treating Radiation-Induced Brain Injury.
RatRadiationSprague-Dawleymalen = 3 rats per group at each time point; total and survival coh…Intraperitoneal injection2 mL/kg body weight; mass concentration not statedBeginning after irradiation on day 1
Model: Whole brain irradiation with a 6 MV electron beam, single fractionated dose of 20 Gy at 2 Gy/min, source to skin distance 100 cm
Endostatin appeared to aggravate cerebral oedema and weight loss in the acute stage and reduced survival by day 56, while lowering oedema progression in the early delayed stage, so the overall effect was mixed and leaned unfavourable.
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