Calpain fosters the hyperexcitability of motoneurons after spinal cord injury and leads to spasticity.
RatSpinal cord injuryComplete transectionWistarn = Twitch time course: 5 rats per group (vehicle, 60 mg/kg, 12…Intraperitoneal injection in vivo; bath application in vitro60 mg/kg or 120 mg/kg in vivo; 30 micromolar bath applied i…Postoperative day 4 to 5, after stable spastic motor behaviour was established
Model: Complete spinal cord transection at T8 to T9 in neonatal rats, with sham laminectomy controls
Acute calpain inhibition dose dependently reduced spasticity signs, limited Nav and KCC2 proteolysis, decreased the persistent sodium current by 16 per cent and increased oligomeric KCC2 by 21 per cent, with no effect in sham or intact animals.
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