Nanoparticles with antioxidant enzymes protect injured spinal cord from neuronal cell apoptosis by attenuating mitochondrial dysfunction.
RatSpinal cord injuryContusionSprague-Dawleymale and femalen = Per-group n not stated; histology quantified on at least th…Intravenous, tail vein30 mg/kg nano-SOD/CAT in 0.8 mL normal saline, each mg cont…6 hours post-injury
Model: Severe T10 contusion spinal cord injury using an Infinite Horizon impactor at 250 kdyn, 10 mm/s, 15 s dwell time, producing complete paraplegia
A single intravenous dose of nano-SOD/CAT at 6 hours partially restored mitochondrial function, lowered reactive oxygen species, cytochrome c and cleaved caspase-3, reduced apoptosis and lesion area and improved weight and locomotor recovery, while free enzyme solution had no significant effect.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.