Protective effects of genipin on ethanol-induced acute gastric injury in mice by inhibiting NLRP3 inflammasome activation.
MouseChemical/toxinmale (per MeSH)Intragastric (oral)Pretreatment, given for 7 days before ethanol challenge
Model: Ethanol induced acute gastric injury, ethanol given for 1 hour
Oral genipin pretreatment reduced ethanol induced gastric mucosal damage, lowered oxidative stress and inflammatory cytokines and suppressed NLRP3 pathway protein expression.
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