A small-molecule activator of mitochondrial aldehyde dehydrogenase 2 reduces the severity of cerulein-induced acute pancreatitis.
MouseChemical/toxinC57BL/6 JMale
Model: Cerulein-induced acute pancreatitis
Alda-1 mediated ALDH2 activation lowered serum pancreatic enzyme levels and the lipid peroxidation products MDA and 4-HNE, decreased Bax and cleaved caspase-3 and increased Bcl-2 both in vivo and in vitro, indicating protection against cerulein-induced acute pancreatitis by mitigating acinar cell a…
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