Prostaglandin D2 signaling is not involved in the recovery of rat hind limb tendons from injury.
RatOtherSprague DawleyMalen = n = 12 rats per group across six experimental groups (72 su…Oral gavage0, 2 or 6 mg/kg per administration, suspended in 0.5% hydro…Given after the tenotomy and immediate repair surgery, with tendons harvested e…
Model: Bilateral full-thickness midsubstance tenotomy of the plantaris tendon followed by immediate surgical repair using a Bunnell technique, with the Achilles tendon left intact as a stress shield
HPGDS inhibition did not alter the functional repair of tenotomised and repaired plantaris tendons at either 7 or 21 days. All repaired tendons showed roughly a sixfold increase in cross-sectional area, about 76% lower peak load and about 95% lower peak stress than uninjured controls, with no diffe…
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