Effect of Polysaccharides from Bletilla striata on the Healing of Dermal Wounds in Mice.
MouseWoundKunmingMalen = Two groups with 20 mice per group; one third of the mice in…Topical, applied to cover the wound areaBSP hydrogel formed from a 40 mg/mL BSP aqueous solution; s…Applied after wound creation, from the day of wounding
Model: Full-thickness excisional dorsal skin wound created with an 8 mm biopsy punch under 2% pentobarbital anaesthesia (45 mg/kg, intraperitoneal)
BSP at 5 and 10 ug/mL slightly promoted L929 fibroblast growth with no cytotoxicity up to 100 ug/mL and enhanced scratch closure by 48 h. In vivo the BSP hydrogel reduced unhealed wound area at days 3 and 6 versus untreated control and was the only group to achieve wound closure within 12 days. Tre…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.