Platelet-Rich Plasma Improves the Wound Healing Potential of Mesenchymal Stem Cells through Paracrine and Metabolism Alterations.
MouseWoundC57BL/6JRjMaleLocal injection into each cutaneous wound100 microlitres of HBSS per wound containing hMADS cells al…Immediately after creation of the skin injuries
Model: Galiano splinted excisional wound model: four circular full-thickness 5 mm diameter cutaneous wounds on the dorsum of each mouse, each surrounded by a silicone splint fixed with adhesive film and 6-0 silk sutures
Combined hMADS plus PRP gave significantly higher wound closure than saline, PRP alone or MSC alone at all time points (80% closure at day 7 versus 43% for saline) and shortened complete closure time to 10.0 plus or minus 0.6 days versus 12.2 plus or minus 1.9 days for saline. Gross, net and recove…
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