Sexual Dimorphism of Gut Microbiota Dictates Therapeutics Efficacy of Radiation Injuries.
Model: Ionising radiation injury: 7 Gy total body irradiation to assess survival, 4 Gy total body irradiation to assess haematopoietic toxicity, and 12 Gy total abdominal irradiation to assess gastrointestinal toxicity. Additional arms used an antibiotic mixture in drinking water to deplete gut microbes and faecal microbiota transplantation from opposite-sex donors for 14 days
Therapeutic efficacy was strictly sex-dependent. Oral simvastatin improved survival and body weight, restored thymus and spleen tissue, lowered peripheral blood IL-6, TNF-alpha and malondialdehyde, preserved colon length, intestinal villi and goblet cells, reduced faecal LCN2 and normalised intesti…
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