Lactobacillus helveticus R0052 alleviates liver injury by modulating gut microbiome and metabolome in D-galactosamine-treated rats.
RatChemical/toxinSprague-DawleyMaleOral gavagePretreatment: administered for 1 week before injury, with D-galactosamine given…
Model: Acute liver injury induced by intraperitoneal injection of D-galactosamine on day 8, with sampling 24 h later
Pretreatment attenuated elevations in aminotransferases, bilirubin and total bile acids and reduced histological hepatic injury. It was anti-inflammatory, downregulating hepatic Toll-like receptors, TNF-alpha and NF-kappa B transcription and lowering plasma proinflammatory cytokines, and it amelior…
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