Pro-inflammatory cytokines serve as communicating molecules between the liver and brain for hepatic encephalopathy pathogenesis and Lycium barbarum polysaccharides protection.
MouseChemical/toxinC57BL/6 (including TNF-alpha and IL-6 knockout lines)MaleOral gavage5 mg/kg in vivo; 50 micrograms/ml in vitro for microglia
Model: Acute hepatic encephalopathy induced by thioacetamide 400 mg/kg intraperitoneally
Thioacetamide produced high mortality, severe hepatic histological injury, increased hepatic oxidative stress and apoptosis, raised circulating pro-inflammatory cytokines and ammonia, suppressed tryptophan hydroxylase activity and impaired locomotor activity. Oral LBP ameliorated these changes, an…
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