Mechanism of KLF4 Protection against Acute Liver Injury via Inhibition of Apelin Signaling.
MouseChemical/toxinC57BL/6MaleTail vein injection10 mg/kg KLF4 plasmid48 h before CCl4 exposure
Model: Acute liver injury from a single intraperitoneal injection of carbon tetrachloride (0.2 mL CCl4 in 100 mL olive oil) at 10 mL/kg; sacrifice 24 h after injection
Mice pre-treated with the KLF4 plasmid showed less hepatic necrosis and steatosis than CCl4-exposed mice given the control GFP plasmid, with significantly lower serum ALT and AST. Hepatic KLF4 mRNA and protein were increased and apelin and cyclin D1 expression were reduced. The authors attribute pr…
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