Protective Effects of MiR-129-5p on Acute Spinal Cord Injury Rats.
RatSpinal cord injuryContusionSprague-DawleyMalen = 36 rats, n = 9 per group across 4 groupsIntrathecal injection into the vertebral canal100 nmol per injectionAfter injury, given under anaesthesia following spinal cord surgery
Model: Acute spinal cord contusion at T10 after laminectomy, modified Allen weight drop apparatus (40 g.cm)
miR-129-5p expression fell by approximately 40 per cent at 12 h after injury and remained reduced to 14 days. Intrathecal miR-129-5p mimic raised BBB scores from day 1 through day 14 versus negative control mimic, reduced tissue loss, damaged cells and TUNEL-positive neurons, and lowered calpain1,…
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