Edaravone attenuates lung injury in a hind limb ischemia-reperfusion rat model: A histological, immunohistochemical and biochemical study.
RatIschaemia-reperfusionLimb / skeletal muscleWistarMalen = 30 adult male rats in 3 groups3 mg/kg30 min before induction of ischaemia
Model: Hind limb ischaemia by femoral artery clamping for 2 h followed by 24 h reperfusion, with remote lung injury
Ischaemia/reperfusion caused focal disruption of alveolar architecture, mononuclear and neutrophil infiltration, dilated congested capillaries, and significantly increased iNOS, NF-kappaB and COX-2 immunoreactivity confirmed by RT-qPCR, with ultrastructural alveolar fluid and red cells and septal v…
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