Critical role of IL-1beta in the pathogenesis of Agrocybe aegerita galectin-induced liver injury through recruiting T cell to liver.

Critical role of IL-1beta in the pathogenesis of Agrocybe aegerita galectin-induced liver injury through recruiting T cell to liver.

Model: Acute liver injury induced by intravenous injection of the fungal lectin Agrocybe aegerita galectin (AAGL), compared with the concanavalin A model

Intravenous AAGL induced infiltration and activation of T, NKT and NK cells in the liver, with T cells central to the pathogenesis. IL-1beta was expressed far more highly in AAGL-treated than concanavalin A-treated mice, and anti-IL-1beta ameliorated AAGL-induced liver injury by inhibiting NF-kappa…

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