Protective effects of zingerone derivate on ionizing radiation-induced intestinal injury.
MouseRadiationC57BL/6J (full text); abstract states C57BL/6NMalen = n = 10 per group in each of the two survival experiments (5…Intragastric (oral gavage)50, 100 or 200 mg/kg in the dose ranging survival study; 10…First dose 1 hour before irradiation
Model: Single 12 Gy abdominal X-irradiation (ABI) at a dose rate of 1.2 Gy per min, producing radiation enteritis
TZC01 100 mg/kg gave the best survival benefit, extending mean survival from 4 days in the solvent group (80% mortality) to 5.5 days, and outperformed zingerone or cysteamine alone (4.5 days each). At 3 days after 12 Gy ABI, crypt number was 41.7% higher and villus length 16.39% greater than solven…
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