Injectable human recombinant collagen matrices limit adverse remodeling and improve cardiac function after myocardial infarction.
MouseIschaemia-reperfusionCardiacC57BL/6 (Cx3cr1-EGFP mice used for monocyte tracking)Femalen = Three to fifteen mice per group as specified in figure lege…Intramyocardial injection via 27-G needle, ultrasound-guided closed-chest procedureFive equivolumetric intramyocardial injections of 10 uL eac…1 week after myocardial infarction, at the end of the proliferative phase
Model: Permanent ligation of the left anterior descending coronary artery via fourth intercostal thoracotomy
rHCI improved ejection fraction from 34.6 plus or minus 1.6% to 44.2 plus or minus 1.9% at 28 days, reduced scar size by about 37%, maintained remote wall thickness and increased border zone capillaries and pro-healing macrophages, whereas rHCIII preserved but did not improve function and PBS-treat…
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