Chronic, Twice-Daily Dosing of an NK2 Receptor Agonist [Lys,MeLeu,Nle]-NKA(4-10), Produces Consistent Drug-Induced Micturition and Defecation in Chronic Spinal Rats.
RatSpinal cord injuryUnspecifiedSprague-Dawley (from MeSH indexing)Male and femaleSubcutaneous for chronic dosing; intravenous and subcutaneous for terminal testing10 ug/kg or 100 ug/kg subcutaneously for chronic dosing; 3…Chronic phase after spinal cord injury; exact interval not stated in retrieved…
Model: Chronic thoracic spinal cord injury
Twice-daily subcutaneous LMN-NKA produced rapid micturition with response rates above 90% and voiding efficiency above 80% in males and above 60% in females, and induced defecation, both remaining stable over 30 days with no tolerance or sensitisation; efficacy was higher in males.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.