Anti-PcrV IgY antibodies protect against Pseudomonas aeruginosa infection in both acute pneumonia and burn wound models.

Anti-PcrV IgY antibodies protect against Pseudomonas aeruginosa infection in both acute pneumonia and burn wound models.

Model: Pseudomonas aeruginosa infected burn wound model and acute pneumonia model in mice

Anti-PcrV IgY induced greater protection than control IgY and phosphate-buffered saline in both the murine acute pneumonia and burn wound models, improved opsonophagocytic killing and inhibited bacterial invasion of host cells.

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