Sodium Valproate Improves Skin Flap Survival via Gamma-Aminobutyric Acid and Histone Deacetylase Inhibitory System.
RatIschaemia-reperfusionOther / unspecifiedSprague-DawleyMaleIntraperitonealAcute treatment 50, 100, 150 or 300 mg/kg; chronic treatmen…Acute treatment 1 h before flap surgery; chronic treatment daily for 2 weeks
Model: Random-pattern skin flap with ischaemic necrosis in rats
Sodium valproate 100 mg/kg significantly reduced the length of skin necrosis in both acute (P < 0.05) and chronic (P < 0.01) treatment, increased weight gain (P < 0.05) and accelerated skin healing (P < 0.001). Bicuculline increased necrosis length and, at a subeffective dose, prevented the protect…
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