Human neural stem cell transplant location-dependent neuroprotection and motor deficit amelioration in rats with penetrating traumatic brain injury.
RatTBIPenetrating / ballisticSprague-DawleyMalen = n = 10 per group randomised across four groups; final footf…Stereotactic intracerebral transplantation into the lesion core or surrounding tissue1 million cells at 50,000 cells/uL; intralesional as a sing…1 week after injury, once motor deficit was established
Model: Unilateral penetrating ballistic-like traumatic brain injury: probe inserted 12 mm through a burr hole and inflated to 6.33 mm diameter for 40 milliseconds
Transplantation one week after penetrating traumatic brain injury attenuated motor deficits at both locations, but only perilesional transplantation reduced lesion volume (9.17 plus or minus 1.53% versus 22.53 plus or minus 2.87% for vehicle) and increased cortical and motor cortex sparing.
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