Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function.
MouseWoundC57BL/6N for eccentric contraction injury; tPA-MG53 transgenic on C57BL/6J background; MG53 knockout; db/dbMale (C57BL/6N eccentric contraction cohort); not stated for other cohortsn = Groups of 10 for the eccentric contraction and recombinant…Intravenous (tail vein) and subcutaneous2 mg/kg intravenously for the time-course study; 0, 0.6, 2,…Intravenous dosing at varying times after injury, still effective at 6 hours; d…
Model: Eccentric contraction-induced skeletal muscle injury (60 tetanic contractions with forced lengthening via sciatic nerve stimulation) and 1 mm through-and-through ear punch wound
Recombinant human MG53 protected against eccentric contraction-induced muscle injury in a time- and dose-dependent manner, and daily subcutaneous dosing from 24 hours after injury improved recovery of contractile function over 28 days versus saline, while transgenic mice with elevated circulating M…
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