Hepatospecific ablation of p38alpha MAPK governs liver regeneration through modulation of inflammatory response to CCl4-induced acute injury.
MouseChemical/toxinMalen = 3 to 10 animals per genotypeIntraperitoneal for carbon tetrachloride, antibodies and BrdU; tamoxifen given in the dietCarbon tetrachloride 0.56 g/kg; tamoxifen diet 1000 mg/kg;…Genetic ablation induced weeks before injury; antibody cocktail given 5 hours b…
Model: Acute liver injury by a single intraperitoneal injection of carbon tetrachloride in sunflower oil (1:9)
Hepatocyte-specific p38alpha deletion protected against carbon tetrachloride-induced acute liver injury by limiting reactive oxygen species and shaping a Ccl2/Ccl5-dependent inflammatory response, and antibody blockade of Ccl2 and Ccl5 abrogated this protection.
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