Clinical-like cryotherapy improves footprint patterns and reduces synovial inflammation in a rat model of post-traumatic knee osteoarthritis.
RatOtherWistarMalen = 32 rats in total, n = 8 per group across four groupsTopical application around the knee held with an elastic band20 g crushed ice pack applied for 20 minutes per session, l…From day 61 after anterior cruciate ligament transection
Model: Anterior cruciate ligament transection of the right knee producing post-traumatic knee osteoarthritis
Cryotherapy increased footprint area by 14% and lowered synovial fluid leukocyte count by at least 95% and cytokine concentrations by at least 55%, but did not change knee skin temperature, joint swelling, thermal threshold, synovitis score or synovial fibrosis.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.