Inhibition of gap junction composed of Cx43 prevents against acute kidney injury following liver transplantation.
MixedIschaemia-reperfusionHepaticSprague-DawleyMaleIntraperitonealHeptanol 0.1 mg/kg; N-acetylcysteine 200 mg/kg1 hour before liver transplantation (pretreatment)
Model: Autologous orthotopic liver transplantation with an anhepatic phase of about 20 plus or minus 1 minutes followed by reperfusion
Heptanol pretreatment inhibited connexin 43 gap junction function and attenuated acute kidney injury after autologous orthotopic liver transplantation, improving creatinine, blood urea nitrogen and tubular histology and reducing oxidative stress, inflammatory cytokines and necroptosis markers, with…
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