Investigation of Bosentan's Effects on Pulmonary Contusion Created by Blunt Thoracic Trauma in Rats.
RatCrushOther / unspecifiedSprague-Dawley (from MeSH indexing)n = 37 rats: contusion day 3 n = 8, bosentan day 3 n = 8, contu…Enteral100 mg/kg/dayStarted after pulmonary contusion; exact interval not stated
Model: Unilateral pulmonary contusion created by dropping a metal weight onto the chest (blunt thoracic trauma)
Bosentan reduced leukocyte infiltration, alveolar oedema and congestion, lowered malondialdehyde and raised superoxide dismutase, and reduced apoptosis, but did not affect fibrosis development or inducible and endothelial nitric oxide synthase levels.
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