Sleep disordered breathing induced by cervical spinal cord injury and effect of adenosine A1 receptors modulation in rats.
RatSpinal cord injuryHemisection / partialSprague-DawleyMaleOral
Model: Left hemisection of the second cervical spinal cord segment (C2Hx), with sham laminectomy as control; breathing assessed at acute (about 1 week) and chronic (about 6 weeks) time points
C2 hemisection raised the apnoea-hypopnoea index relative to sham (35.5 plus or minus 12.6 versus 19.1 plus or minus 2.1 events per hour, p less than 0.001). Oral DPCPX significantly reduced the apnoea-hypopnoea index four days after treatment compared with placebo (69.5 plus or minus 8.9 per cent…
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