MicroRNA 223 3p Negatively Regulates the NLRP3 Inflammasome in Acute and Chronic Liver Injury.
MouseEndotoxin/LPS
Model: Lipopolysaccharide/D-galactosamine-induced endotoxin acute hepatitis, and fibrotic non-alcoholic steatohepatitis induced by long-term high-fat, fructose and cholesterol diet
miR-223 3p reduced inflammatory cell infiltration and pro-inflammatory cytokine and chemokine expression in endotoxin acute hepatitis, and mitigated fibrosis and hepatic stellate cell activation in fibrotic NASH, with disrupted NLRP3 inflammasome activation in both models.
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