Mitigation of radiation-induced gastro-intestinal injury by the polyphenolic acetate 7, 8-diacetoxy-4-methylthiocoumarin in mice.
MouseRadiationC57BL/6femaleIntraperitoneal5 microgram/kg in 100 microlitre24 h after total body irradiation
Model: Sub-lethal total body gamma irradiation at 7.6 Gy from a cobalt-60 teletherapy unit at 1 Gy/min, causing radiation-induced intestinal injury
DAMTC preserved crypt and villus architecture and restored xylose absorption through day 21, markedly reduced crypt and stromal apoptosis, lowered DNA damage markers and lipid peroxidation, and increased proliferation and antioxidant enzyme levels.
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