Acute Kahweol Treatment Attenuates Traumatic Brain Injury Neuroinflammation and Functional Deficits.
MouseTBIControlled cortical impactC57BL/6 wild-typeMalen = 218 mice in total: 43 for brain water content, 15 for cytok…Intraperitoneal, dissolved in dimethyl sulfoxideSingle dose of 5, 10 or 20 mg/kg; continuous regimen used a…Administered immediately after traumatic brain injury induction
Model: Controlled cortical impact through a 5 mm craniotomy over the right parietal cortex, 2.5 mm rounded tip, 4 m/s velocity, 2 mm deformation depth
Single doses of 5 and 10 mg/kg reduced contusion volume (17.63 and 15.71 mm3 versus 20.70 mm3 for vehicle at day 3) and brain water content, and improved neurological severity score, beam score, beam walking and rotarod performance; 20 mg/kg did not differ from vehicle. The 5 mg/kg dose reduced Flu…
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