Topical Application of a Mast Cell Stabilizer Improves Impaired Diabetic Wound Healing.
MouseWoundTopical, delivered by controlled release from specifically designed alginate bandagesApplied both before wounding and after wounding
Model: Excisional skin wounding in diabetic mice
Topical MCS-01 applied before or after wounding accelerated wound healing in diabetic mice to an extent comparable with systemic mast cell stabilisation, promoted classically activated macrophage polarisation, and modulated the wound mRNA and microRNA profile with upregulation of acute inflammation…
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