Therapeutic efficacy of neuregulin 1-expressing human adipose-derived mesenchymal stem cells for ischemic stroke.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-Dawleymalen = Behaviour: n=26 NRG1-AdMSCs, n=18 AdMSCs, n=10 adenoviral N…Intracerebral stereotaxic injection into the left lateral striatum (0.7 mm anterior to bregma, 3.2 mm lateral, 5.5 mm below dura) over 5 min5 microlitres of AdMSC suspension in PBS; adenoviral NRG1 c…1 day after middle cerebral artery occlusion
Model: Transient focal cerebral ischaemia by intraluminal silicone-coated filament occlusion of the left middle cerebral artery for 60 min followed by reperfusion
NRG1-AdMSCs lowered modified Neurological Severity Scores and reduced infarct volume at 14 days compared with PBS, adenoviral NRG1 and naive AdMSCs, with higher exogenous and endogenous NRG1 and raised ErbB4, pMAPK and pAkt in the ischaemic hemisphere.
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