Mitigating Effects of 1-Palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) on Hematopoietic Acute Radiation Syndrome after Total-Body Ionizing Irradiation in Mice.
MouseRadiationBALB/cmale and female50 mg/kg and 250 mg/kgPost-irradiation, including delayed administration at 48 h and 72 h after gamma…
Model: Single-fraction gamma-ray total-body irradiation causing haematopoietic acute radiation syndrome
PLAG dose-dependently attenuated radiation-induced mortality and body weight loss, delayed onset and shortened duration of severe neutropenia, and mitigated thrombocytopenia and anaemia; delayed dosing at 48 h and 72 h still improved survival.
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