Administration of a 20-Hydroxyeicosatetraenoic Acid Synthesis Inhibitor Improves Outcome in a Rat Model of Pediatric Traumatic Brain Injury.
RatTBIControlled cortical impactSprague-Dawleymalen = n=10 per injured group at 3 days, n=7 HET0016 at 30 days; p…Intraperitoneal injection1 mg/kgFirst dose 5 min after controlled cortical impact
Model: Controlled cortical impact through a left parietal craniotomy, 3 mm flat-tipped impactor at 5.5 m/s, 50 ms dwell, 1.5 mm dural displacement, modelling infant and toddler traumatic brain injury
HET0016 approximately halved lesion volume at 3 days (6.2% versus 12.9%) and at 30 days (8.8% versus 18.2%), reduced contralateral hindlimb foot faults, restored novel object discrimination, blunted early TNF-alpha and IL-1beta and preserved microglial ramification.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.