CGRP-dependent and independent mechanisms of acute and persistent post-traumatic headache following mild traumatic brain injury in mice.
MouseTBIWeight-drop / impact-accelerationC57Bl/6JmaleDosing regimens tested at 2 h, 7 days and 14 days after injury; also a single d…
Model: Mild traumatic brain injury by weight drop allowing free head rotation under minimal anaesthesia, with sham procedure controls; bright light stress used at 2 weeks as a provocative stimulus for persistent post-traumatic headache
Early and continuous anti-CGRP antibody dosing attenuated injury-induced cutaneous allodynia and prevented bright light stress-induced allodynia, whereas a single delayed dose given after central sensitisation was established did not prevent stress-induced allodynia.
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