Embelin can protect mice from thioacetamide-induced acute liver injury.
MouseChemical/toxinC57BL/6femaleintragastric gavage50 microgram per gram body weightStarted 2 days before thioacetamide administration
Model: Thioacetamide-induced acute liver injury (single injection, 300 microgram per gram body weight)
Embelin pretreatment improved survival and liver function relative to thioacetamide alone, reduced hepatic necrosis and apoptosis, and brought forward inflammatory cell infiltration, fibrogenesis and macrophage activity consistent with earlier healing.
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