Helenalin from Centipeda minima ameliorates acute hepatic injury by protecting mitochondria function, activating Nrf2 pathway and inhibiting NF-kappaB activation.

Helenalin from Centipeda minima ameliorates acute hepatic injury by protecting mitochondria function, activating Nrf2 pathway and inhibiting NF-kappaB activation.

Model: Lipopolysaccharide (50 microgram/kg) plus D-galactosamine (800 mg/kg) induced acute liver injury

Helenalin reduced histopathological liver damage, serum aminotransferase and bilirubin levels, hepatocyte apoptosis, oxidative stress and inflammatory cytokine production in lipopolysaccharide/D-galactosamine-induced acute liver injury.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.